Smart Guide,WKYMVm is a selective agonist of the N-formyl peptide receptor

The search for WKYMVm peptide for sale leads to a specialized market catering to scientific research and development. This synthetic hexapeptide, also known as W peptide or WKYMVM, is recognized for its potent activity as an agonist for various formyl peptide receptors (FPRs), primarily FPR1, FPR2, and FPR3. Understanding its properties and where to procure it is crucial for researchers investigating its therapeutic potential.

Understanding WKYMVm Peptide: Properties and Applications

WKYMVm is a synthetic peptide that plays a significant role in modulating immune responses. It acts as a selective agonist for the formyl peptide receptors, which are expressed on immune cells like leukocytes. These receptors are crucial for initiating and regulating inflammatory processes. Specifically, WKYMVm is a selective agonist for the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM). This potent activity makes it a valuable tool for studying formyl peptide receptor signaling pathways.

The peptide's ability to activate these receptors has been linked to several biological effects, including:

* Chemoattraction: WKYMVm is a potent chemoattractant that enhances leukocyte activity via activation of FormylPeptideReceptor-Like 1 (FPRL1). This means it can draw immune cells to sites of inflammation or injury.

* Anti-inflammatory Effects: Despite its role in initiating immune responses, WKYMVm has also demonstrated significant anti-inflammatory properties, showing potential in reducing lung injury and spinal cord injury.

* Immune Modulation: WKYMVM-NH2 is a hexapeptide that activates neutrophils and myeloid cells through the FPRL1 and FPR2 receptors, with EC50 values of 2 nM for HL-60-FPRL1.

* Phospholipase Activation: Research indicates that WKYMVm is found to stimulate phospholipase C (PLC)-mediated formation of InoPs in certain cell lines. WKYMVm also activates phospholipase.

Furthermore, WKYMVm is recognized as a Formyl Peptide Receptor-Like 1 Agonist. Its interaction with these receptors is a key area of focus in scientific research, leading to its application in studies involving inflammatory arthritis and other conditions associated with immune dysregulation.

Where to Find WKYMVm Peptide for Sale

When looking for WKYMVm peptide for sale, several reputable suppliers offer this research chemical. These vendors typically provide detailed product specifications, including purity levels (often ≥95% (HPLC)), CAS numbers (e.g., CAS No. : 187986-17-0), and available quantities. Common packaging sizes include 1 mg and 0.5 mg, with prices varying accordingly. For instance, a 1 mg quantity might range from approximately $89.00 to $140.00 or more, depending on the supplier and any additional modifications like labeling.

Some suppliers offer variations such as WKYMVM-NH2 or WKYMVm-amide, which are structurally similar and also available for purchase. You may also find WKYMVm amide – Rhodamine Labeled for applications requiring fluorescent tracking.

Key considerations when purchasing include:

* Purity: Ensure the peptide meets the required purity standards for your research, typically indicated by HPLC (High-Performance Liquid Chromatography) analysis.

* Form: Decide whether you need the standard WKYMVm, the amidated form (WKYMVM-NH2), or a labeled version.

* Quantity and Pricing: Compare prices and available quantities from different vendors. Some sites may offer select research peptides at limited-time, reduced pricing or on sale.

* Supplier Reputation: Choose suppliers with a strong track record in providing high-quality research chemicals and excellent customer service. Experts in Peptide Research often have decades of experience.

* Shipping and Availability: Check if the product is in stock and inquire about shipping options, especially if expedited delivery is needed. Many suppliers offer free shipping on qualifying orders.

Related Peptides and Research

While searching for WKYMVm peptide for sale, you might encounter information on related compounds and research areas. For example, WRW4 is a specific formyl peptide receptor-like 1 (FPRL1) antagonist that inhibits WKYMVm binding to FPRL1 with an IC50 of 0.23 µM. This antagonist is also available for research purposes.

The broader field of peptide research includes other compounds like KPV peptide. Buy KPV peptide online for research from reputable sources offering high purity. Research-grade KPV peptide for sale in 10mg vials is also accessible.

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